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How to Use
If you take several doses per day, take the missed dose as soon as you remember it and take any remaining doses for that day at evenly spaced intervals. However, if it is almost time for the next dose
, skip the missed dose and continue your regular dosing schedule.
If you take Zyban once a day at bedtime and do not remember to take it until the next morning, skip the missed dose. Do not t
ake a double dose to make up for a missed one.
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Symptoms of overdose may include:
Quitting smoking, with or without Zyban treatment, could change the way your body metabolizes certain drugs, for example, theophylline and warfarin (Coumadin). Make sure your doctor knows all the pres
cription and over-the-counter medicines you're taking.
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Possible food and drug interactions when taking this medication
When you are taking Zyban, it is especially important that your health care professional know if you are taking any of the following:
- Alcohol or
- Antipsychotics (medicine for mental
illness) or
- Corticosteriods(cortisone-like medicine) or
- Fluoxetine (e.g., Prozac) or
- Lithium (e.g., Lithane) or
- Maprotiline (e.g., Ludiomil) or
- Theophylline (e.g., S
omophyllin-T) or
- Trazodone (e.g., Desyrel) or
- Ritonavir (e.g., Norvir)¡XUsing these medicines with Zyban may increase the risk of seizures
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Precautions Before Using This Medicine
A variety of conditions can predispose you to seizures, including:
- Prior head injuries
- Prior seizures
- Central nervous system tumors
- Cirrhosis of the liver
- Too m
uch alcohol
- Abrupt withdrawal from alcohol, tranquilizers, or sedatives
- Addiction to narcotics or cocaine
- Use of over-the-counter stimulants or diet pills
- Use of diabetes m
edications
- Use of antidepressants, major tranquilizers, steroids, or theophylline
If any of these apply to you, use Zyban with care. If you do have a seizure while taking Zyban, stop
taking the drug and never take it again.
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What is this medicine
Zyban was introduced in the USA in 1985 and was withdrawn in 1986 because of an unacceptable incidence of seizures. In 1989 it was reintroduced in the USA (maximum dose of 450 mg daily). Zyban was fir
st approved in Canada in 1998 as an SR twice-daily formulation. In one RCT buproprion SR, 150 mg daily and 150 mg BID, were similar and more effective than placebo based on physician rated scores of d
epression at 8 weeks.8 In 2 RCTs Zyban (150-400 mg/day) was similar in effectiveness to sertraline (50-200 mg/day) at 8 weeks, but the incidence of satisfaction with sexual functioning was less with s
ertraline (63%) than buproprion (79%) and placebo (78%). 9, 10
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Special warnings about this medication
Your doctor should check your progress at regular visits, especially during the first few months of treatment with this medicine. The amount of Zyban you take may have to be changed often to meet the
needs of your condition and to help avoid unwanted effects.
Do not take Zyban within 14 days of taking an MAO inhibitor.
Zyban is sold under different brand names for different uses.
If you are already taking medicine for mental depression or to help you stop smoking, discuss this with your health care professional before taking Zyban. It is very important that you receive only o
ne prescription for Zyban at a time.
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